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. 2024 May 8;16(1):2347715. doi: 10.1080/19490976.2024.2347715

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© 2024 Société des Produits Nestlé SA. Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 4. — Overview of changes in plasma tryptophan, N-Acetyl tryptophan, and associations with clinical endpoints.

A) Concentrations of tryptophan in plasma at baseline (V1) and end of intervention (V2) per group, B) Correlation between the difference of HADD score (V2-V1) and tryptophan concentration in plasma at V2; Spearman test. C) Correlation between amygdala activation (fMRi) and tryptophan concentration in plasma at V2; Spearman test. D) Concentrations of N-acetyltryptophan in plasma at baseline (V1) and end of intervention (V2) per group, E) Correlation between the difference in HADD score (V2-V1) and N-acetyltryptophan concentration in plasma at V2; Spearman test. F) Correlation between amygdala activation (fMRi) and plasma N-acetyl-tryptophan concentration at V2; Spearman test. BL NCC3001 (BL, open circle); Placebo (P, closed circle).