Table 1.
Overview of plasma metabolite differences according to treatment and time.
| Metabolites (unit) | OPLS parameters. |
Blood concentrations (Mean (SD)) |
P-value Pre | P-value Post | ||||
|---|---|---|---|---|---|---|---|---|
| Coeff | VIP | Placebo Pre | Placebo Post | BL NCC3001 Pre | BL NCC3001 Post | |||
| Arachidic acid (ng/mL) | 0.34 | 1.32 | 258.1 (233.6) | 143.4 (142.9) | 212 (143.7) | 241.5 (147.6) | 0.476 | 0.057 |
| Arachidonic acid (ng/mL) | 0.29 | 1.24 | 74831.5 (33085.7) | 73022.8 (23563.8) | 85945.1 (44065.4) | 95695.5 (43008.9) | 0.403 | 0.043 |
| Butyric acid (ng/mL) | 0.48 | 1.83 | 91.5 (45.9) | 72.0 (29.6) | 65 (25) | 103.5 (37.2) | 0.038 | 0.008 |
| Docosatrienoic acid (ng/mL) | 0.26 | 1.28 | 14736.4 (6929.5) | 14035.0 (6178.5) | 14103.9 (4891.4) | 18435.1 (7955) | 0.752 | 0.064 |
| Eicosapentaenoic acid (ng/mL) | 0.27 | 1.18 | 389870.2 (148890.7) | 387660.8 (140034.1) | 436787.9 (195879.5) | 475388.7 (171320.1) | 0.429 | 0.077 |
| Ethylmethylacetic acid (ng/mL) | 0.39 | 1.48 | 30.2 (63.9) | 34.5 (71.8) | 33.6 (67.3) | 89 (88.2) | 0.881 | 0.050 |
| GCA (nM) | 0.43 | 1.63 | 331.2 (632.3) | 258.7 (158) | 385.2 (291.2) | 602.2 (786.1) | 0.739 | 0.085 |
| GCDCA (nM) | 0.47 | 1.76 | 1069.2 (1042.4) | 980.8 (707.6) | 1371.9 (887.7) | 1807.2 (1632.6) | 0.347 | 0.061 |
| GUDCA (nM) | −0.30 | 1.16 | 35.6 (61.1) | 69.7 (128.5) | 54.9 (106) | 17.6 (23.4) | 0.508 | 0.108 |
| L-Asparagine (ng/mL) | 0.21 | 1.17 | 9083.2 (4325.8) | 9021.8 (4593.8) | 9555.4 (2702.9) | 10726 (1283.3) | 0.694 | 0.155 |
| L-Tryptophan (ng/mL) | 0.37 | 1.58 | 16181.8 (4381.5) | 15788.6 (4257.6) | 17504.5 (1917.2) | 17740.3 (1537.6) | 0.244 | 0.081 |
| Malic acid (ng/mL) | −0.21 | 1.19 | 255.1 (302.9) | 497.9 (679.3) | 340.7 (472.3) | 331.4 (404.5) | 0.528 | 0.372 |
| N-acetyl-tryptophan (ng/mL) | 0.40 | 1.75 | 36953.1 (12532.5) | 35349.5 (11388.5) | 40921.5 (8513.5) | 41968.6 (6827.7) | 0.271 | 0.044 |
| Oleic acid (ng/mL) | 0.24 | 1.35 | 407483.2 (119185) | 372474.5 (120852.2) | 377034.6 (140261.3) | 447659.5 (140379.6) | 0.491 | 0.131 |
| Palmitic acid (ng/mL) | 0.31 | 1.46 | 166557.1 (46476.1) | 156101.2 (44850.9) | 169164.7 (46423.7) | 189971.6 (40260.8) | 0.868 | 0.024 |
| Stearic acid (ng/mL) | 0.35 | 1.54 | 126420.4 (42195.5) | 117539.2 (29871.9) | 123284.8 (46273.5) | 141693.9 (34051.4) | 0.834 | 0.028 |
| TUDCA (nM) | −0.38 | 1.46 | 29.1 (27.4) | 51.6 (36) | 26.9 (25) | 30.3 (20.4) | 0.806 | 0.052 |
Legend: Coeff: OPLS Correlation coefficient, VIP: OPLS Variable Importance in Projection; p-value: Wilcoxon signed rank test between placebo and BL NCC3001 group post intervention.