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. 2024 May 7;20(1):2342592. doi: 10.1080/21645515.2024.2342592

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© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 3. — Ultra-high performance liquid chromatography (UHPLC) analysis of four lipid components of mRNA-LNPs. (a) Differences in changes of mPEG-DMG-2K in formulation stored at 4°C for 0, 3, and 6 months. (b) Differences in changes in cholesterol of the fractions after 0, 3 and 6 months of storage at 4°C. (c) Analysis of lipid content of the ionizable lipid (SM-102) in formulation fractions of different particle sizes. (d) Analyze differences in changes in DSPC after 0, 3 and 6 months of storage at 4°C.Calculations are described in the ‘Lipid Content Determination’ section of materials and methods. MOI%: the percentage of lipid content detected in the sample as a percentage of the labeled amount. Data were analyzed by a two-tailed unpaired t-test. *P < .05, **P < .01, ***P < .001. All panels were analyzed in triplicate.