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. 2024 May 7;20(1):2342592. doi: 10.1080/21645515.2024.2342592

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© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 7. — Humoral and cellular immune responses in mice immunized with the mRNA vaccine. Mice were immunized intramuscularly with 5 µg of mRNA vaccine, with a booster of the same dose 7 days after the first vaccination. (a) A schematic diagram of vaccination and sampling in mice. (b,c) Double antibody sandwich assay for determining the levels of IFN-γ and IL-4 in the serum of the mRNA-LNPs immunized mouse. (d,e) Serum levels of total IgG1/IgG2a were measured using ELISA kits. (f) ELISA for the determination of SARS-CoV-2 receptor binding domain-specific IgG antibody titers in immunized animals. Data are shown as mean ± SD, two-way analysis of variance (n $= 6$ ; ns p > .05, *p < .05, **p < .01, ***p < .001, ****p < .0001).