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. 2024 May 9;15(1):2350904. doi: 10.1080/21505594.2024.2350904

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© 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 1. — F. nucleatum increased along with CRC progression and AI-2 accumulation (a) Representative images of FISH detecting F. nucleatum in CRC and NC tissues. (b) qRT-PCR data showed the significantly increased abundance of F. nucleatum in CRC tissues (n = 40) compared with that in NC tissues (n = 40). The relative abundance of F. nucleatum in tissues was estimated by qRT-PCR using the specific primers targeting F. nucleatum, and primers targeting gapdh were used to confirm the equal quantity of tissues. (c) qRT-PCR data showed the increased abundance of F. nucleatum along with the cancer progression. (d) the concentration of AI-2 is significantly higher in CRC tissues compared with NC tissues, and (e) increased along with the cancer progression. (f) Pearson’s correlation analysis showed a positive correlation between F. nucleatum abundance and AI-2 concentration in tissues of CRC patients.

****p < 0.0001, **p < 0.01. *p < 0.05. F. nucleatum, Fusobacterium nucleatum; CRC, colorectal cancer; AI-2, auto-inducer-2; FISH, Fluorescent in Situ Hybridization; NC, adjacent normal control.