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. 2024 May 9;15(1):2350904. doi: 10.1080/21505594.2024.2350904

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© 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 2. — NE increased with the progression of F. nucleatum related CRC (a) the concentration of NE was significantly higher in CRC tissues (n = 40) compared with NC tissues (n = 40). (b) the concentration of NE in tumours increased along with the progression of CRC. (c, d) Pearson’s correlation analysis showed positive correlation between NE concentration and F. nucleatum abundance (c) or AI-2 concentration (d) in CRC tissues.

****P < 0.0001, **P < 0.01. CRC, colorectal cancer; NC, adjacent normal control; NE, norepinephrine; F. nucleatum, Fusobacterium nucleatum; AI-2, auto-inducer-2.