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. 2024 May 9;15(1):2350904. doi: 10.1080/21505594.2024.2350904

Figure 4.

Figure 4.

AI-2 is essential for NE enhanced virulence and proliferation of F. nucleatum (a) statistics of AI-2 concentration in the supernatant of F. nucleatum culture induced by NE. (b) Representative images illustrating the colony formation of F. nucleatum subjected to NE treatments with and without AI-2 inhibitor. (c) statistics of F. nucleatum density based on the colonies in (b). (d) qRT-PCR data showed that D-Rib significantly inhibited the FadA expression of F. nucleatum induced by NE. All experiments were repeated three times, and paired t test was used.

*P < 0.05, **P < 0.01, ***P < 0.001. F. nucleatum, Fusobacterium nucleatum; NC, Negative control; NE, norepinephrine; D-Rib, D-Ribose; AI-2 competitive inhibitor.