Figure 7.

SCFA relieved intestinal damage caused by the plateau environment.

(a) HE staining of duodenum, jejunum, and ileum of the CON, HPBS, NaPr, and NaBu groups (n = 5, bar = 50 μm). (b–d) The villi length of the duodenum, jejunum, and ileum, respectively. (e) Immunohistochemical staining of occludin in duodenal tissue sections of CON, HPBS, NaPr, and NaBu groups (bar = 50 μm). (f) Mean IOD of occludin in the duodenum. (g,i) Immunohistochemical staining of ZO-1(g) and occludin(i) in colon tissue sections of CON, HPBS, NaPr, and NaBu groups (bar = 20 μm). (h,j) Mean IOD of ZO-1(h), occluding(j) in the colon. Con/C: control group; HPBS/HP: high-altitude PBS group; NaBu/Bu: high-altitude butyrate group; NaPr/Pr: high-altitude propionate group. The results are expressed as Mean±SE (n = 5). “*” stands for significant difference. *p < 0.05. **p < 0.01. ***p < 0.001. ****p < 0.0001. The p value is calculated by t-test.