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. 2024 May 10;10(19):eadm7515. doi: 10.1126/sciadv.adm7515

Fig. 2. RhCMV elicits robust and durable T cell responses to TAAs.

Fig. 2.

(A) Six male RMs were inoculated with 68-1 RhCMV/RhPAP and with 68-1 RhCMV/SIVgag. RMs 1 to 3 were additionally coinoculated with RhCMV/WT-1, whereas RMs 4 to 6 were coinoculated with 68-1 RhCMV/MSLN. At day 140, RMs 1 to 3 received 68-1 RhCMV/MSLN, whereas RMs 4 to 6 received 68-1 RhCMV/WT-1. (B) CD4+ and CD8+ T cell responses were measured in peripheral blood mononuclear cells (PBMCs) using overlapping peptide pools for each of the antigens by ICS for CD69 and IFNγ and/or TNFα at each of the indicated time points. The background subtracted mean response frequencies are shown (+SEM). Days of inoculation are indicated by arrowheads. Individual response frequencies are shown in data file S3.