Fig. 5. Rh189-deleted 68-1 RhCMV elicits canonical MHC-Ia–restricted T cells to SIV Gag but not to TAAs.

Six RMs were coinoculated with 68-1 RhCMVΔRh189 expressing the indicated antigens as shown in fig. S3. MHC restriction of individual 15–amino acid oligomer peptides from each antigen for CD8⁺ T cells from four RMs of this cohort was determined as described in Fig. 3. Above background responses are shown as squares at the position along the antigen with the colors indicating blocking by reagents specific for MHC-II (blue), MHC-E (green), or MHC-Ia (red). Supertope peptides are shown by boxes. Indeterminate responses are shown in purple. Overall analysis of 15–amino acid oligomer peptide responses is shown in data file S3.