Database	Period of search	Search strategy
Cochrane Central Register of Controlled Trials (CENTRAL) (Wiley)	Issue 3 of 12, 2013.	#1 laparoscop* OR coelioscop* OR celioscop* OR peritoneoscop* #2 cholecystectom* #3 MeSH descriptor Cholecystectomy, Laparoscopic explode all trees #4 (( #1 AND #2) OR #3) #5 MeSH descriptor Pain explode all trees #6 MeSH descriptor Anesthetics, Local explode all trees #7 Intraperitoneal morphine OR intraperitoneal meperidine OR NSAID OR Ketorolac OR diclofenac OR Indomethacine OR Paracetamolo OR tenoxicam OR parecoxib OR valecoxib intraperitoneal bupivacaine OR thoracic epidural analgesia OR opioids analgesia OR preemptive gabapentin OR clonidine OR ketamine OR esmolol #8 (#4 OR #5 OR #6 ) #9 pain OR ache* OR suffering* #10 (#8 OR #9) #11 (#4 AND #5 AND #6 AND #10)
MEDLINE (PubMed)	1987 to March 2013.	laparoscop* OR coelioscop* OR celioscop* OR peritoneoscop*) AND (cholecystectom* OR "cholecystectomy, laparoscopic"[MeSH]) AND (Analgesia OR bupivacain* OR buvacaina OR sensorcaine OR marcain* OR svedocain* OR levobupivacaine OR ropivacaine OR Ketorolac OR diclofenac OR Indomethacine OR Paracetamolo OR tenoxicam OR parecoxib OR valecoxib OR ntraperitoneal morphine OR intraperitoneal meperidine OR intraperitoneal bupivacaine OR thoracic epidural analgesia OR opioids analgesia OR preemptive gabapentin OR clonidine OR ketamine OR esmolol AND ("Pain"[Mesh] OR pain OR ache* OR suffering*) AND (((randomized controlled trial [pt] OR controlled clinical trial [pt] OR randomized controlled trials [mh] OR random allocation [mh] OR double‐blind method [mh] OR single‐blind method [mh] OR clinical trial [pt] OR clinical trials [mh] OR ("clinical trial" [tw]) OR ((singl* [tw] OR doubl* [tw] OR trebl* [tw] OR tripl* [tw]) AND (mask* [tw] OR blind* [tw])) OR (placebos [mh] OR placebo* [tw] OR random* [tw] OR research design [mh:noexp]) NOT (animals [mh] NOT human [mh]))))
EMBASE (OvidSP)	1987 to March 2013.	1. exp crossover‐procedure/ or exp double‐blind procedure/ or exp randomized controlled trial/ or single‐blind procedure/ 2. (((((random* or factorial* or crossover* or cross over* or cross‐over* or placebo* or double*) adj blind*) or single*) adj blind*) or assign* or allocat* or volunteer*).af. 3. 1 or 2 4. (laparoscop* or coelioscop* or celioscop*OR peritoneoscop*).af. 5. exp laparoscopic surgery/ 6. 4 or 5 7. cholecystectom*.af. 8. exp cholecystectomy/ 9. 7 or 8 10. (analgesia or ketorolac or diclofenac or indomethacin or paracetamol or tenoxicam or parecoxib or valdecoxib or morphine or meperidine or opioid or opiate).af. 11. exp analgesia/ 12. 10 or 11 13. (pain or ache* or suffering*).af. 14. exp pain/ 15. 13 or 14 16. 3 and 6 and 9 and 12 and 15
Science Citation Index Expanded (Web of Knowledge)	1987 to March 2013.	#1 TS=(laparoscop* OR coelioscop* OR celioscop* OR peritoneoscop*) #2 TS=(cholecystectom*) #3 TS=(pain OR ache* OR suffering* OR Preemptive analgesia OR pain control OR Multimodal analgesia) #4 TS=(NSAID OR Ketorolac OR diclofenac OR Indomethacine OR Paracetamolo OR tenoxicam OR parecoxib OR valecoxib OR intraperitoneal morphine OR intraperitoneal meperidine OR intraperitoneal bupivacaine OR thoracic epidural analgesia OR opioids analgesia OR preemptive gabapentin OR clonidine OR ketamine OR esmolol) #5 #3 OR #4 #6 #5 AND #4 AND #3 AND #2 AND #1