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. 2014 Mar 28;2014(3):CD008261. doi: 10.1002/14651858.CD008261.pub2

Wilson 1994.

Methods Randomised clinical trial.
Participants Country: England.
 Number randomised: 55.
 Post‐randomisation drop‐outs: 6 (10.9%).
 Revised sample size: 49.
 Mean age: 48 years.
 Females: 40 (81.6%).
 Inclusion criteria:
  1. People undergoing laparoscopic cholecystectomy.


Exclusion criteria:
  1. Peptic ulcer disease.

  2. Hepatic or renal insufficiency.

  3. History of haemorrhagic diathesis.

  4. Hypersensitivity to diclofenac.

Interventions Participants were randomly assigned to 1 of 2 groups.
 Group 1: diclofenac 75 mg IM (n = 26).
 Group 2: placebo (n = 23).
Outcomes Pain.
Notes Reasons for post‐randomisation drop‐outs: incomplete data extraction (n = 3), conversion to open (n = 3).
Attempts were made to contact authors in August 2013.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Quote: "Computer random number generation".
Allocation concealment (selection bias) Unclear risk Comment: This information was not available.
Blinding of participants and personnel (performance bias) 
 All outcomes Low risk Quote: "Pharmacy provided identical pre‐packed syringes".
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk Comment: This information was not available.
Incomplete outcome data (attrition bias) 
 All outcomes High risk Comment: There were post‐randomisation drop‐outs.
Selective reporting (reporting bias) High risk Comment: Mortality and morbidity were not reported.
For‐profit bias Unclear risk Comment: This information was not available.