Table 2. Details of the course of transplantation and bradycardia.
| No. | Type of donor | Conditioning protocols* | TCI | HCT-CI | CSA start dosage [mg] | Day of CSA treatment when bradycardia occurred | Heart rate (HR) and ECG record at first episode of arrythmia | CSA concentration when bradycardia occurred [ng/mL] | Electrolyte levels when bradycardia occurred [mmol/l] | Duration of bradycardia [days] | Treatment of bradycardia |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. | MUD | FluBu3 | RIC/RTC | 2 | 260 | 2 | HR = 35/min; sinus bradycardia | 116 | [Ca2+] = 7,8 [K+] = 4,3 [Mg2+] = 1,52 [Glc] = 80 |
3 | CSA withdrawal, multi-electrolyte fluids infusion |
| 2. | MUD | RituxFluTBI 4Gy | NMA | 4 | 300 | 4 | HR = 42/min; sinus bradycardia | 131,8 | [Ca2+] = 8,7 [K+] = 4,2 [Mg2+] = 2,03 [Glc] = 89 |
1 | CSA withdrawal |
| 3. | MUD | FluBu4 | MAC | 3 | 220 | 2 | HR = 44/min; sinus bradycardia | 122 | [Ca2+] = 8,5 [K+] = 4,5 [Mg2+] = 2,03 [Glc] = 86 |
2 | CSA withdrawal, multi-electrolyte fluids infusion |
| 4. | Haploidentical | BFR | NMA | 0 | 200 | 1 | HR = 35/min; sinus bradycardia | 108,3 | [Ca2+] = 8,3 [K+] = 4,2 [Mg2+] = 1,71 [Glc] = 114 |
1 | CSA withdrawal |
| 5. | MUD | Cy/TBI 12 Gy | MAC | 0 | 200 | 2 | HR = 38/min; sinus bradycardia | 127 | [Ca2+] = 7,9 [K+] = 4,4 [Mg2+] = 1,6 [Glc] = 96 |
4 | CSA and beta-blocker withdrawal, multi-electrolyte fluids infusion, atropine intravenously |
| 6. | MUD | FluTBI | NMA | 3 | 300 | 4 | HR = 50/min; sinus bradycardia | 156,6 | [Ca2+] = 8,3 [K+] = 5,3 [Mg2+] = 1,66 [Glc] = 99 |
1 | CSA withdrawal |
Abbreviations: HSC – hematopoietic stem cells, TCI – transplant conditioning intensity, HCT-CI - Hematopoietic Cell Transplantation-specific Comorbidity Index, CSA – cyclosporine A, MUD – matched unrelated donor, SIB – sibling, FluBu3-4 – fludarabine and busulfan, RituxFluTBI – rituximab, fludarabine and total body irritation, BFR – bendamustine, fludarabine and rituximab, Cy/TBI – cyclophosphamide and total body irritation, FluTBI – fludarabine and total body irritation, RIC/RTC – reduced intensity conditioning/reduced toxicity conditioning, NMA – non-myeloablative conditioning, MAC – myeloablative conditioning
*All regimens and drug dosages were administrated according to the European Bone Marrow Transplantation (EMBT) recommendation