TABLE 2.
Summary of Adaptive Optics Scanning Laser Ophthalmoscopy Measures From Baseline to 2-Years – Individual Grader Data
| Outcomes | Alla | Grader 1 | Grader 2 | Grader 3 | |||
|---|---|---|---|---|---|---|---|
| USH2 | ARRP | USH2 | ARRP | USH2 | ARRP | ||
| Baseline | N = 1146, n = 14 | N = 153, n = 6 | N = 228, n = 8 | N = 155, n = 6 | N = 228, n = 8 | N = 154, n = 6 | N = 228, n = 8 |
| Z-score | |||||||
| Mean (SD) | 1.36 (2.55) | 1.95 (3.04) | 1.33 (2.13) | 1.31 (2.51) | 0.70 (2.23) | 2.33 (3.07) | 1.06 (2.24) |
| Median (IQR) | 0.86 (−0.27 to 2.45) | 0.88 (0.03-2.77) | 0.96 (−0.13 to 2.37) | 0.92 (−0.22 to 2.61) | 0.26 (−0.56 to 1.70) | 1.60 (0.20-4.03) | 0.82 (−0.56 to 2.22) |
| Range | −4.37 to 13.95 | −4.27 to 13.95 | −2.40 to 8.96 | −3.97 to 12.25 | −4.37 to 8.72 | −3.38 to 12.67 | −3.30 to 7.95 |
| Cone density (cones/mm2) | |||||||
| Mean (SD) | 22,827 (8752.4) | 25,402 (8153.9) | 23,810 (9103.0) | 23,380 (10221) | 24,334 (9460.4) | 19,772 (6041.5) | 20,294 (7302.7) |
| Median (IQR) | 21,457 (16,936-27,311) | 24,435 (20,312-29,552) | 22,207 (17,168-27,864) | 21,615 (16,237-30,006) | 23,033 (18,368-28,134) | 19,161 (15,453-23,558) | 19,332 (15,424-23,731) |
| Range | 2252-64,616 | 10,007-64,616 | 8566-60,196 | 2252-62,074 | 6503-64,561 | 7921-37,410 | 4017-51,382 |
| Cone spacing (arcmin) | |||||||
| Mean (SD) | 1.36 (0.23) | 1.35 (0.26) | 1.41 (0.25) | 1.29 (0.22) | 1.33 (0.21) | 1.37 (0.19) | 1.37 (0.21) |
| Median (IQR) | 1.33 (1.20-1.48) | 1.31 (1.18-1.51) | 1.37 (1.23-1.56) | 1.30 (1.13-1.43) | 1.30 (1.19-1.43) | 1.37 (1.22-1.51) | 1.33 (1.23-1.46) |
| Range | 0.72-2.26 | 0.72-2.26 | 0.83-2.20 | 0.79-2.10 | 0.81-2.20 | 0.87-1.78 | 0.90-2.26 |
| 1 year | N = 254, n = 12 | N = 45, n = 12 | N = 78, n = 12 | N = 53, n = 12 | N = 78, n = 12 | ||
| Z-score | |||||||
| Mean (SD) | 1.53 (2.57) | 1.50 (2.41) | 1.42 (2.47) | 2.11 (3.16) | 1.26 (2.29) | ||
| Median (IQR) | 1.09 (−0.24 to 2.90) | 0.85 (−0.17 to 2.99) | 0.96 (−0.41 to 2.85) | 1.36 (0.43-3.83) | 0.89 (−0.48 to 2.70) | ||
| Range | −3.13 to 12.95 | −1.57 to 10.83 | −2.67 to 8.43 | −3.13 to 12.95 | −2.96 to 8.49 | ||
| Cone density (cones/mm2) | |||||||
| Mean (SD) | 20,173 (7830.6) | 23,263 (7385.6) | 20,540 (8800.0) | 19,763 (6516.6) | 18,301 (7402.7) | ||
| Median (IQR) | 19,028 (14,529-23,954) | 22,766 (18,091-28,586) | 18,453 (14,152-24,072) | 18,597 (14,330-24,224) | 17,563 (12,146-22,512) | ||
| Range | 4682-52,298 | 9064-38,227 | 8038-52,298 | 8411-32,406 | 4682-47,411 | ||
| Cone spacing (arcmin) | |||||||
| Mean (SD) | 1.39 (0.25) | 1.35 (0.22) | 1.43 (0.29) | 1.35 (0.22) | 1.43 (0.29) | ||
| Median (IQR) | 1.36 (1.22-1.49) | 1.32 (1.20-1.43) | 1.37 (1.24-1.62) | 1.32 (1.20-1.43) | 1.37 (1.24-1.62) | ||
| Range | 0.89-2.26 | 0.95-2.07 | 0.89-2.26 | 1.01-1.80 | 0.99-2.20 | ||
| 2-year | N = 261, n = 14 | N = 51, n = 14 | N = 62, n = 14 | N = 55, n = 14 | N = 93, n = 14 | ||
| Z-score | |||||||
| Mean (SD) | 1.80 (2.78) | 2.55 (3.50) | 1.54 (2.39) | 2.37 (3.33) | 1.31 (2.21) | ||
| Median (IQR) | 1.22 (0.01-2.92) | 1.62 (0.61-3.21) | 1.21 (−0.09 to 2.73) | 1.35 (0.41-3.14) | 0.81 (−0.21 to 2.70) | ||
| Range | −3.12 to 15.27 | −1.31 to 14.87 | −3.12 to 8.42 | −1.71 to 15.27 | −3.05 to 7.76 | ||
| Cone density (cones/mm2) | |||||||
| Mean (SD) | 21,835 (8334.0) | 23,578 (8802.1) | 22,314 (9072.1) | 21,371 (8046.3) | 20,674 (7339.6) | ||
| Median (IQR) | 20,411 (15,983-26,765) | 22,645 (17,622-28,644) | 20,611 (15,771-27,252) | 20,285 (15,137-27,040) | 19,307 (15,845-24,393) | ||
| Range | 8082-55,206 | 9737-44,948 | 8082-55,206 | 8828-40,767 | 8544-46,887 | ||
| Cone spacing (arcmin) | |||||||
| Mean (SD) | 1.37 (0.23) | 1.38 (0.27) | 1.37 (0.24) | 1.37 (0.26) | 1.35 (0.19) | ||
| Median (IQR) | 1.33 (1.20-1.46) | 1.35 (1.18-1.50) | 1.34 (1.20-1.44) | 1.30 (1.18-1.55) | 1.32 (1.22-1.43) | ||
| Range | 0.80-2.04 | 0.80-2.04 | 0.97-2.00 | 0.95-2.02 | 1.00-2.00 | ||
IQR = interquartile range; SD = standard deviation.
a
N indicates the number of region of interest gradings; n is the number of participants.