Figure 2. Serum Cytokine (N = 123) (A) and Inflammatory Laboratory (N = 270) (B) Levels (Estimated Marginal Means) Over Time Compared Between Those With and Without a Cognitive Symptoms at 18 Months.

The dark green line represents patients with cognitive symptoms at 18 months, and the blue line represents those without cognitive symptoms at 18 months (with error bars). All cytokine and inflammatory laboratory levels significantly declined over time (all Friedman p < 0.001), with the exception of IL-1ß (Friedman p = 0.738). There were no significant differences in the areas under the curves of any cytokine or inflammatory laboratory measure when comparing those with or without 18-month cognitive symptoms (all p > 0.05).