Table 2. Top ten CpG sites from the epigenome-wide association study of DNA methylation with the Area Deprivation Index, stratified by the presence or absence of the APOE ε4 allele.

				Total (n=159)		ε4 present (n=89)		ε4 absent (n=70)		Effect modification
CpG	Chromosome	Position	Gene(s)	Effect estimate	P-value	Effect estimate	P-value	Effect estimate	P-value	P-value
cg26514961	12	94566784	PLXNC1	-0.0052	5.0e-8	-0.0050	0.0033	-0.0008	0.0002	8.7e-6
cg08087060	16	87795808	KLHDC4	-0.0040	5.7e-7	-0.0036	0.0030	-0.0007	0.0009	4.6e-5
cg01291468	2	234589374	UGT1A10;UGT1A7; UGT1A9;UGT1A8	0.0034	1.4e-6	0.0027	0.0098	0.0004	0.0019	0.0003
cg05419854	17	19398395	-	-0.0058	1.8e-6	-0.0042	0.0190	-0.0008	0.0004	1.0e-5
cg16241648	7	98923114	ARPC1A	0.0016	2.1e-6	0.0018	0.0046	0.0003	0.0020	0.0002
cg20912923	8	2885516	CSMD1	-0.0026	2.5e-6	-0.0021	0.0083	-0.0002	0.0008	3.1e-5
cg15953452	3	63053400	-	-0.0050	2.5e-6	-0.0042	0.0105	0.0008	0.0001	6.2e-6
cg06787422	15	63331851	-	-0.0024	3.1e-6	-0.0015	0.0411	-0.0002	0.0012	0.0001
cg13521319	9	133423844	-	-0.0018	3.4e-6	-0.0020	0.0019	-0.0001	0.0046	0.0007
cg09431774	22	25465561	KIAA1671	-0.0028	3.6e-6	-0.0020	0.0249	-0.0002	0.0002	8.6e-6

Bold: statistically significant at the Bonferroni threshold of 6.33e-8.

Effect estimates can be interpreted per a 20-unit increase in ADI. All models were adjusted for the following covariates: race, sex, educational attainment, age at death, apolipoprotein E (APOE) genotype, cell type, and post-mortem interval.