Table 3. Association between the top ten CpG sites from the epigenome-wide association study of Area Deprivation Index (compare Table 2), and their association with neuropathology markers (CERAD, ABC and Braak stage).
| CERAD1 | ABC2 | Braak stage | ||||
| CpG | Chromosome | Position | Gene(s) | Effect estimate (95%-CI) | Effect estimate (95%-CI) | Effect estimate (95%-CI) |
| cg26514961 | 12 | 94566784 | PLXNC1 | 0.41 (-0.85, 1.67) | 0.67 (-0.35, 1.70) | 0.41 (-0.78, 2.56) |
| cg08087060 | 16 | 87795808 | KLHDC4 | 0.57 (-1.17, 2.32) | 0.08 (-1.47, 1.63) | 0.57 (-2.73, 1.92) |
| cg01291468 | 2 | 234589374 |
UGT1A10;UGT1A7;
UGT1A9;UGT1A8 |
-1.20 (-3.50, 1.09) | -1.14 (-3.13, 0.82) | -1.20 (-4.67, 1.49) |
| cg05419854 | 17 | 19398395 | - | -0.89 (-2.17, 0.37) | -0.39 (1.50, 0.71) | -0.89 (-1.05, 2.52) |
| cg16241648 | 7 | 98923114 | ARPC1A | 0.93 (-3.42, 5.30) | -1.08 (-4.96, 2.77) | 0.93 (-6.89, 5.12) |
| cg20912923 | 8 | 2885516 | CSMD1 | 0.46 (-2.25, 3.18) | 1.54 (-0.66, 3.77) | 0.46 (-1.82, 5.46) |
| cg15953452 | 3 | 63053400 | - | 0.11 (-1.33, 1.55) | 0.56 (-0.62, 1.75) | 0.11 (-0.66, 2.93) |
| cg06787422 | 15 | 63331851 | - | -0.13 (-3.33, 3.06) | 0.50 (-2.22, 3.22) | -0.13 (-3.20, 4.94) |
| cg13521319 | 9 | 133423844 | - | -1.37 (-5.24, 2.46) | -0.69 (-4.24, 2.84) | -1.37 (-6.76, 4.03) |
| cg09431774 | 22 | 25465561 | KIAA1671 | 0.37 (-2.17, 2.91) | -0.10 (-2.41, 2.21) | 0.37 (-4.31, 2.78) |
1Consortium to Establish a Register for AD; 2Amyloid, Braak, and CERAD.
Effect estimates can be interpreted per a 0.1-unit increase in DNAm. All models were adjusted for the following covariates: race, sex, educational attainment, age at death, apolipoprotein E (APOE) genotype, cell type, and post-mortem interval.