Figure 4.

Crystal structures of the HLA‐B*18:01 binding cleft, presenting four immunogenic influenza peptides. (a) Structural overlay of the peptide backbone and anchor positions (cartoon) for NP₂₁₉ (cyan), M1₅ (green), NS2₁₁₁ (yellow) and PB1₁₁₇ (pink), within the binding cleft of HLA‐B*18:01 (light cyan). Side view of the HLA‐B*18:01 binding cleft presenting NP₂₁₉ (b), M1₅ (c) and their overlay (d). Side view of the HLA‐B*18:01 binding cleft presenting PB1₁₁₇ (e), NS2₁₁₁ and their overlay (f). (b–g) Peptide residue side chains are represented in stick. (h) Top‐down view of NS2₁₁₁ is represented as a transparent surface (white) within the binding cleft of HLA‐B*18:01 (light cyan cartoon).