Table 1.

Gross pathology scoring system consisting of scores for morbidity and mortality, ascites production, local tumor extension, and tumor deposits in various organs

Category	Score	Description
Morbidity and Mortality	0	Bright, alert, active; normal behavior and ambulation, no clinical signs
	1	Mild lethargy or mild hunching, able to ambulate to reach food and water, active when observed cage side, no other clinical signs
	2	Moderate lethargy or moderate hunching, able to ambulate to reach food and water, responsive when cage is handled
	3	Moribund, minimal response when cage is handled, unable to ambulate to reach food and water
	4	Found dead or euthanized prior to experimental endpoint
Ascites	0	None
	1	Mild
	2	Moderate
	3	Severe
Local Tumor Extension	0	None
	1	Mild, <1 cm
	2	Moderate, 1-2 cm
	3	Severe, >2 cm
Tumor Deposits in Spleen, Mesentery, Liver	0	None
	1	Focal or <2 mm tumor nodules
	2	Multifocal or >2 mm tumor nodules
	3	Diffuse tumor nodules or infiltration of tumor into organ