FIG. 1.

EAV genome organization and expression. (Top) EAV genome organization and the nested set of sg mRNAs (RNAs 2 to 7). Black boxes, common leader sequences; gray boxes, ORFs expressed from each sg mRNA. (Bottom) ORF1a and ORF1ab replicase polyproteins. The ORF1a-encoded protease domains and their corresponding cleavage sites are indicated with white or shaded boxes and arrowheads, respectively. Black boxes, hydrophobic domains and conserved ORF1b-encoded domains. Abbreviations: P, papainlike cysteine protease; C, cysteine protease; H, hydrophobic domain; S, serine protease; RdRp, putative RNA-dependent RNA polymerase; M, predicted MBD; Hel, putative helicase domain; N, conserved nidovirus-specific domain.