Skip to main content
. 2024 May 10;15:3976. doi: 10.1038/s41467-024-48328-8

Fig. 5. Macrophage-specific Thbd knockout decreases erythropoiesis.

Fig. 5

A Protocol to prepare Thbdf/f;LysM mice. B Fech expression in F4/80+CD169+Vcam-1+ macrophages of Thbdf/f;LysM mice (n = 5). C Heme content in F4/80+CD169+Vcam-1+ macrophages of Thbdf/f;LysM mice (n = 5). D PB RBC numbers, Hb, and HCT of Thbdf/f;LysM mice (n = 5). E Frequency of RIII and RIV erythroblast populations in Thbdf/f;LysM mice (n = 5). F Frequency of apoptotic erythroblasts among BM cells in Thbdf/f;LysM mice (n = 5). G EBI numbers in the BM of Thbdf/f;LysM mice (n = 5). H EBI numbers in the spleen of Thbdf/f;LysM mice (n = 5). I PB RBC numbers, Hb, and HCT of Thbdf/f;LysM mice after PHZ treatment (n = 5). J Frequency of RIII and RIV erythroblast populations in Thbdf/f;LysM mice 6 d after PHZ treatment (n = 5). K Heme content in F4/80+CD169+Vcam-1+ macrophages of Thbdf/f;LysM mice after rTFPI treatment (n = 5). L PB RBC numbers, Hb, and HCT in Thbdf/f;LysM mice after rTFPI treatment (n = 5). Statistical analysis was performed using one-way ANOVA (B-J). Data are shown as mean ± SEM and are representative of two (C-L) or three B independent experiments. Source data are provided as a Source Data file.