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. 2024 May 10;15:3974. doi: 10.1038/s41467-024-48072-z

Fig. 1. MAGMA-seq is an integrated technology for antibody wide mutational scanning.

Fig. 1

a Protocol schematic. b Yeast surface titrations of 4A8 and CC12.1 Fabs against Fc-conjugated S1 in the established (light) and updated (dark) yeast surface display vectors. Cytograms from indicated data points are shown for updated yeast surface backbones. Inset describes experimentally determined KD values (n = 2). c Antibodies assessed using updated yeast surface display vectors. RBD Receptor Binding Domain Wuhan Hu-1, NTD N Terminal Domain Wuhan Hu-1, NA influenza neuraminidase N2 A/Brisbane/10/2007, HA influenza hemagglutinin A/Brisbane/02/2018 H1. Source data are provided as a Source Data file.