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. 2024 May 10;15:3969. doi: 10.1038/s41467-024-48287-0

Fig. 2. Molecular modeling and expression analysis of p.R841H WWP2 variant.

Fig. 2

A Overview of the HECT domain structure and its two main lobes. B Zoom on Arg841 and its neighbors. Arg841 and Cys838 are respectively shown in orange and black ball and stick. The residues involved in the ionic and hydrogen bond network are shown in sticks. Residues with carbons colored in yellow are within 5 A from Arg841 (pdb id:4y07). C The expression of p.R841 and p.R841H WWP2 protein was determined by SDS-PAGE/immunoblotting under reducing conditions in cell lysates of TLR3-expressing 293 T cells after different times of transfection. Results represent 1 experiment among 3. TLR3 FL TLR3 full length.