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. 2024 May 10;15:3969. doi: 10.1038/s41467-024-48287-0

Fig. 6. WWP2-dependent HSV-1 replication in iPSCs-derived neurons.

Fig. 6

A Quantification of the number of plaque-forming units (pfu) by plaque-titration at different time after infection of neurons from WWP2 p.R841 individuals (black, N = 3) and from WWP2 p.R841H individuals (red, N = 6). (B) Quantification of the number of plaque-forming units (pfu) by plaque-titration at 48 h after infection of neurons from WWP2 WT individuals (black, N = 3) and from WWP2 p.R841H individuals (red, N = 5) without or with an IFNα2b pretreatment (+IFN). Figure shows median of one experiment. Statistical analyses were performed using an unpaired two-tailed Student t-test. The purple triangle and the grey square correspond to patient with HSE and to patient’s father respectively. A *, ** mean for P = 0.0005 and P = 0.0002. B *, **, *** mean for P = 0.0239, P = 0.0256 and P = 0.0039.