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. 2024 May 10;15:3969. doi: 10.1038/s41467-024-48287-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — A Induction of IFNβ mRNA after 1 h of Poly(I:C) stimulation in neurons from WWP2 p.R841H (red, N = 2), WWP2 p.H841R (grey, N = 2) individuals and WWP2 p.R841 controls (black, N = 3). B Induction of IFNβ mRNA after 1 h of Poly(I:C) stimulation in neurons from WWP2 p.R841 (black, N = 2), WWP2 p.R841H (grey, N = 2) individuals and WWP2 p.H841 controls (red, N = 4). Results represent the mean ± standard error of 1 experiment among 2. C Quantification of the number of viral genome in neurons from WWP2 p.R841H (red, N = 2), WWP2 p.H841R (grey, N = 2) individuals, and WWP2 p.R841 controls (black, N = 4), without or with an IFNα pretreatment (+IFN). D Quantification of the number of viral genome in neurons from WWP2 p.R841 (black, N = 2), WWP2 p.R841H (grey, N = 1) individuals and WWP2 p.H841 controls (black, N = 7) without or with an IFNα pretreatment (+IFN). E Quantification of the number of plaque-forming units (pfu) by plaque-titration after infection of neurons from WWP2 p.R841H (red, N = 2), WWP2 p.H841R (grey, N = 2) individuals and WWP2 p.R841 controls (black, N = 3) without or with an IFNα2b pretreatment (+IFN). F Quantification of the number of plaque-forming units (pfu) by plaque-titration after infection of neurons from WWP2 p.R841 (black, N = 2), WWP2 p.R841H (grey, N = 2) individuals and WWP2 p.H841 controls (black, N = 4) without or with an IFNα2b pretreatment (+IFN). G Quantification of the number of plaque-forming units (pfu) by plaque-titration at different time after infection of neurons from WWP2 p.R841H (red, N = 2), WWP2 p.H841R (grey, N = 2) individuals and WWP2 p.R841 controls (black, N = 3). A significant effect (*) of the rescue (grey) compared to allele carrier (red) (p = 2.41e-5) was found using a linear regression on log10 + 1 transformed pfu with a time-dependent effect. H Quantification of the number of plaque-forming units (pfu) by plaque-titration at different time after infection of neurons from WWP2 p.R841 (black, N = 2), WWP2 p.R841H (grey, N = 2) individuals and WWP2 p.H841 controls (black, N = 4). A significant effect (*) of the mutant induced (pink) compared to control (black) (p = 2.06e-3) was found using a linear regression on log10 + 1 transformed pfu with a time-dependent effect.