Table 3. Predictors of the disease progression to death, acute exacerbation, and induction of LTOT in patients with fibrotic HP.
| Variable | Univariable analysis | Multivariable analysis | |||
|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | ||
| Age | 1.02 (0.95–1.09) | 0.66 | |||
| Male | 0.78 (0.30–1.99) | 0.60 | |||
| Never smoker | 0.87 (0.33–2.33) | 0.78 | |||
| KL-6 (U/mL) | 1.00 (1.00–1.00) | 0.49 | |||
| SP-D (ng/mL) | 1.00 (1.00–1.00) | 0.36 | |||
| BAL lymphocytes (%) | 0.99 (0.97–1.01) | 0.37 | |||
| FVC %predicted (%) | 0.96 (0.94–0.99) | 0.02 | 0.99 (0.95–1.02) | 0.41 | |
| DLco %predicted (%) | 0.97 (0.95–0.99) | 0.004 | 0.98 (0.94–1.01) | 0.16 | |
| Desaturation in the 6-min walk test (%) | 1.18 (1.05–1.34) | 0.006 | 1.12 (0.95–1.02) | 0.12 | |
| The UIP patten group | 8.84 (1.16–67.29) | 0.03 | 10.43 (1.18–92.07) | 0.03 | |
LTOT, long-term oxygen therapy; HP, hypersensitivity pneumonitis; HR, hazard ratio; CI, confidence interval; KL-6, Krebs von den Lungen-6; SP-D, surfactant protein D; BAL, bronchoalveolar lavage; FVC, forced vital capacity; DLco, diffusing capacity of lung for carbon monoxide; UIP, usual interstitial pneumonia.