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. 2024 Apr 29;121(19):e2307156121. doi: 10.1073/pnas.2307156121

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Copyright © 2024 the Author(s). Published by PNAS.

This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 7. — Striatal cholinergic and parvalbumin-expressing interneuron density is normal in Celsr3 and Wwc1 mutant mice. (A) Representative images showing striatal CINs (ChAT+, green) and PVINs (PV+, magenta) in Celsr3^C1906Y/+ mice and littermate controls. (B) Quantification of CIN (Left, P = 0.2220) and PVIN density (Middle, P = 0.7735) in Celsr3^+/+ (n = 6) and Celsr3^C1906Y/+ (n = 6) mice, and cumulative frequency distribution of nearest neighbor (NN) distance of CINs and PVINs (right, Celsr3^+/+: solid curve, Celsr3^C1906Y/+: dashed curve). (C) Representative images showing striatal CINs (ChAT+, green) and PVINs (PV+, magenta) in Celsr3^S1894Rfs*2/+ mice and littermate controls. (D) Quantification of CIN (left, P = 0.8090) and PVIN (Middle, P = 0.1000) density in Celsr3^+/+ (n = 6) and Celsr3^S1894Rfs*2/+ (n = 6) mice, and cumulative frequency distribution of NN distance of CINs and PVINs (Right, Celsr3^+/+: solid curve, Celsr3^S1894Rfs*2/+: dashed curve). (E) Representative images showing striatal CINs (ChAT+, green) and PVINs (PV+, magenta) in Wwc1^W88C/+ mice and littermate controls. (F) Quantification of CIN (Left, P = 0.4579) and PVIN (Middle, P = 0.2077) density in Wwc1^+/+ (n = 6) and Wwc1^W88C/+ (n = 6) mice, and cumulative frequency distribution of NN distance of CINs and PVINs (right, Wwc1^+/+: solid curve, Wwc1^W88C/+: dashed curve). All statistical comparisons were made using Welch’s t tests.