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13 weeks 2 days ultrasound scan of Case 1.
a) Sagittal ultrasound shows absent nasal bone and increased nuchal translucency (arrowhead). No echogenic nasal bone below the echogenic skin line (arrow); b) The transverse view showing poorly displayed cranial halo (arrows), suggesting poorly ossified cranium; c) Poorly ossified vertebral spine (arrows) is easily seen as echo-poor, nearly black vertebral bodies.
