Table 2.

DMT-harmala-based variables that may reduce adverse effects in hospital-based research.

Preparation/Screening	Dosage	Set and Setting	Integration
To ensure the desired outcomes during the therapy sessions, proper preparation is vital. Patients need to be fully informed about the risks and benefits of treatment, including potential side effects. 16	Dosing should be carefully considered, ideally by both the participant and the administrator.	An important factor that influences the outcome of therapy is the mindset or ‘set’ of patients. Patients should approach this with an open mindset, being willing to explore their inner selves and confront any negative emotions or traumas that may arise during sessions.	After the therapy session, it is important to offer adequate integration support to patients. 66
	Appropriate doses may differ depending on the participant.		This can include follow-up therapy sessions, group meetings, or individual check-ins to help the patient process and integrate their experiences.
The patient can be aided through the use of preparatory sessions prior to treatment, where patients can learn relaxation techniques and receive guidance on managing challenging experiences.	Numerous factors should be considered, such as the weight of the participant, previous psychedelic experience, and the intention of the participant. 67	The setting in which DMT-harmala-based therapy is administered should be carefully chosen to ensure comfort and safety for patients. 67	This support can help patients better understand and integrate the insights gained from their therapy sessions into their daily lives, potentially leading to long-term benefits for their mental health.
Additionally, patients should undergo a thorough psychiatric evaluation before being approved for therapy to screen for any underlying mental health or physical conditions that may exacerbate the risks of treatment. 71	A series of controlled clinical trials described ayahuasca dosages as: low (.5 mg/DMT/kg), medium (.75 mg/DMT/kg), and high (1 mg–1.4 mg//DMT/kg). a 65	The environment should be welcoming with comfortable seating and space for patients to lie down if necessary. It should also be free from distractions and provide privacy for patients to explore their inner experiences. Participants should be accompanied by a therapist with whom they feel safe.

^aThe data above are only presented as examples.