Figure 2.

Salicylate increased the MT of IC neurons

(A) A sharply tuned single unit with a CF of 9.5 kHz showed a clear elevation of the MT from 0 (left panel) to 35 (right) dB SPL in the presence of salicylate.

(B) A more broadly tuned unit showed an elevation of MT from 5 (left) to 30 (right) dB SPL and a shift of CF from 22.6 to 19 kHz. White outlines in A and B indicate the borders of significant tuning obtained from the FACA.

(C) Most units showed an increase in MT (paired two-tailed t-test, ∗∗∗ denotes p < 10⁻⁴). Blue and green dimensionality lines show the change in MT of example units shown in (A) and (B), respectively. Red line shows the mean MT in baseline or salicylate. Error bars denote SDs.

(D) Changes in MT were observed across the range of CFs. Relation between threshold shifts induced by salicylate and CF under baseline conditions. CFs were slightly jittered for display to avoid overlap.

(E) Relationship between the magnitude of the salicylate threshold shift and the unit’s baseline CF. A parabolic function was fitted to the data: $\Delta MT=-55.66{\left(\log CF\right)}^2+124.48\log CF-44.21$, where $\Delta MT$ is the change in MT in dB SPL and CF is expressed in kHz. The same jitter in CF from (D) was applied to each datapoint.

Related to Figure 1.