Extended Data Fig. 3 |. Pacing at a physiological rate does not induce contractile dysfunction in EHTs.

EHTs (SCVI-273) were tachypaced or unpaced for 10 days and contractility measurements were performed on days 0, 2, 7, and 10. Functional parameters generated from the analysis include maximum contraction velocity (a), maximum relaxation velocity (b), spontaneous beating rate (c), and contractile force (d). n = 16 for unpaced EHTs and n = 14 for paced EHTs. Two-way ANOVA with Bonferroni’s multiple comparisons test. Data are displayed as mean ± s.e.m.