Table 4.
Unadjusted associations of the three brain injury biomarker factors with the exposures of interest (n = 95).
| Exposure | Brain injury biomarker factorsa | |||||
|---|---|---|---|---|---|---|
| 1 | 2 | 3 | ||||
| Est (95% CI) | p | Est (95% CI) | p | Est (95% CI) | p | |
| Sex: Male vs Female (ref) |
0.31 (− 0.09, 0.72) |
0.131 |
0.04 (− 0.37, 0.45) |
0.849 |
− 0.08 (− 0.49, 0.33) |
0.708 |
| Age: Neonate vs Non-neonate (ref) |
− 0.23 (− 0.63, 0.18) |
0.276 |
0.29 (− 0.12, 0.69) |
0.166 |
− 0.32 (− 0.73, 0.08) |
0.119 |
| ECMO indication: Non-respiratory vs Respiratory (ref) |
0.78 (0.37, 1.18) |
< 0.001 |
0.34 (− 0.09, 0.77) |
0.118 |
− 0.19 (− 0.62, 0.25) |
0.390 |
ECMO, extracorporeal membrane oxygenation; CI, confidence interval.
aBrain injury biomarker factors:
Factor 1: GFAP, S100β, MCP1, VILIP-1, NSE, BDNF, NRGN.
Factor 2: NPTX1, vWF, PDGFRβ.
Factor 3: BDNF, MMP-9.