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Schematic diagram of the TVTM series of retroviral escort proteins. TVTMs were designed to target retroviral vectors to the tumor vasculature. TVTM1, TVTM2, and TVTM3 bind selectively to up-regulated integrins in in vitro panning assays and accumulate selectively in the tumor vasculature in vivo. TVTM4, TVTM5, and TVTM6 represent novel designs.
