Table 2.

Primary and secondary outcomes

Variables	Fibrinogen	Placebo	P -value (Kruskal- Wallis Test)
Total bleeding, median (IQR), mL	1100 (605.00)	1300 (405.00)	0.001
Hb baseline, median (IQR), g/dL	11.70 (1.65)	11.60 (2.00)	0.635
Hb recovery, median (IQ)R, g/dL	10.40 (1.55)	9.90 (1.75)	0.008
Hb 24 h, median (IQR), g/dL	10.90 (1.25)	10.90 (1.50)	0.611
PLT baseline, median (IQR), /microliter	186.00 (55.00)	202.00 (70.50)	0.359
PT baseline , median (IQR), s	12.00 (1.50)	12.00 (1.80)	0.388
PTT baseline , median (IQR), s	27.00 (7.45)	24.30 (6.35)	0.720
INR baseline , median (IQR)	1.00 (0.10)	1.00 (0.10)	0.486
Fibrinogen baseline, median (IQR), mg/dL	241.00 (127.00)	234.00 (107.00)	0.941
Fibrinogen recovery, median (IQR), mg/dL	237.00 (116.00)	200.98 (104.00)	0.012
Fibrinogen 24 h, median (IQR). mg/dL	222.00 (84.50)	216.00 (94.00)	0.599
Changes in fibrinogen levels, median (IQR), ng/dL	9.00 (10.00)	38.00 (18.50)	<0.001
Cases of blood transfusions, median (IQR), numbers	0.00 (1.00)	1.00 (1.00)	0.004
Packed cell used for transfusion, median (IQR), numbers	0.00 (1.00)	1.00 (1.00)	0.007

IQR: interquartile range; HB: hemoglobin, PLT: platelet count; PT: prothrombin time; APTT: activated partial thromboplastin time; INR: international normalized ratio