Skip to main content
. 2024 Mar 20;52(2):639–650. doi: 10.1042/BST20230479

Figure 3. Schematic illustration of the interaction of the lipid pathway with other signaling pathways for the regulation of pluripotency.

Figure 3.

Lipids (FA, fatty acid) enhance ERK activity by increasing ERK phosphorylation (p-ERK elevation). The ERK signaling pathway, in turn, modulates TBX3 expression, where TBX3 acts as a transcriptional regulator for Nanog expression. Lipids can also engage with additional signaling pathways that impact Nanog expression, thereby influencing the pluripotency state of ESCs.