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Genetic reasons to urgently initiate ACE inhibition (or ARB) prior to proteinuria onset
| Situation | Meaning |
|---|---|
| All men with X-linked Alport syndrome | Presence of a COL4A5 variant in a man |
| All individuals with digenic Alport syndrome | A variant in any 2 of the 3 COL4 genes |
| All individuals with autosomal recessive Alport syndrome | Two variants in the same COL4 gene (homozygous variants) |
