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. 2024 May 13;3(1):14. doi: 10.1007/s44162-024-00036-z

Table 8.

What symptoms and signs indicate a diagnosis of Alport syndrome?

Persistent blood in the urine (microscopic haematuria) especially when there is a family history of blood in the urine or kidney issues
Protein in the urine (Proteinuria) or kidney failure when there is no other obvious cause
Cases in the family of ‘IgA nephropathy’ (IgAN). IgA nephropathy may coincidentally co-exist with Alport syndrome and this can look like a family history of IgAN
Cases of focal segmental glomerulosclerosis (FSGS)—especially if this condition does not respond to steroid treatment or if there are other possible cases in the family
Hearing loss or eye features, such as fleck retinopathy
Kidney cysts should make one think of Alport syndrome, especially if PKD1/2 variants (which cause autosomal dominant polycystic kidney disease) are not found