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. 2024 May 12;57:26. doi: 10.1186/s40659-024-00509-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Impact of sexual dimorphism on the liver transcriptomic and proteomic profiles of mice treated with different concentrations of ascorbate. (A) Principal Component Analysis (PCA) on the transcriptomic data. (B) One-dimensional Gene Ontology analysis showing the fold enrichments of genes involved in biological processes significantly different between females and males. (C) PCA graph of Gulo^−/− mice treated with different concentrations of ascorbate in drinking water since weaning compared to age-matched control untreated WT mice in both females and males. (D) One-dimensional Gene Ontology analysis showing the fold enrichments of proteins involved in biological processes significantly different between females and males. For the PCA graphs, F = Females and M = Males; WT00 = WT females or males with no ascorbate for 4 months; GL00 = Gulo^−/− females or males with no ascorbate for 1 month; GL01 = Gulo^−/− females or males treated with 0.01% ascorbate for 4 months; GL05 = Gulo^−/− females or males treated with 0.05% ascorbate for 4 months; GL40 = Gulo^−/− females or males treated with 0.4% ascorbate for 4 months; GLR40 = Gulo^−/− females or males treated with 0% ascorbate for 1 month followed by 1 month of 0.4% ascorbate treatment; N = 3 for each experimental groups