TABLE 8.
Summary of parameters of methylamine after multiple-dose administration.
| Placebo (n = 6) | 20 mg (n = 6) | 40 mg (n = 6) | 100 mg (n = 6) | |
|---|---|---|---|---|
| D1 | ||||
| Emax (ng/mL) | 1.752 ± 2.717 | 46.816 ± 10.016 | 69.899 ± 20.913 | 104.866 ± 29.801 |
| TEmax(h) | 0 (0∼8) | 24.0 (12∼24) | 24.0 (12∼24) | 24.0 (24∼24) |
| AUEC0–24h (h*ng/mL) | 4.703 ± 9.142 | 798.335 ± 192.147 | 1,123.438 ± 240.662 | 1,602.930 ± 407.876 |
| D7 | ||||
| Emax (ng/mL) | 6.329 ± 0.999 | 139.638 ± 23.639 | 124.142 ± 31.114 | 156.070 ± 41.355 |
| TEmax(h) | 6.500 (0.25∼48) | 12.000 (1∼24) | 24.000 (12∼24) | 24.000 (0∼24) |
| AUEC0–24h (h*ng/mL) | 46.773 ± 50.536 | 3,159.315 ± 589.373 | 2,695.048 ± 807.601 | 3,409.268 ± 843.084 |
| AUEC0–48h (h*ng/mL) | 84.240 ± 102.283 | 5,616.318 ± 983.937 | 5,004.718 ± 1,505.139 | 6,504.433 ± 1,606.539 |
| AUEC0–168h (h*ng/mL) | 324.640 ± 354.935 | 11,035.448 ± 1,651.001 | 10,034.358 ± 3,617.607 | 14,665.223 ± 3,932.953 |
Data are presented as the mean (standard deviation), except for TEmax, which is shown as the median (min, max).
Abbreviations: Emax, maximum concentration of methylamine; TEmax, time to reach maximum concentration of methylamine; AUEC0–24h (48 h, 168 h), area under the concentration–time curve from time zero to 24 h (48 h, 168 h).