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. 2024 Mar 21;45(18):1647–1658. doi: 10.1093/eurheartj/ehae100

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© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kidney function is improved at 3 months in patients receiving inorganic nitrate. Panel A shows the change in serum creatinine concentration at 3 months from baseline with a significant decrease in the inorganic nitrate group compared to the placebo group (−10.42 (95% confidence interval: −14.98 to −5.86), P < .001; difference as estimated by linear regression adjusting for baseline creatinine and diabetes status). Panel B shows the change in eGFR concentration at 3 months from baseline with a significant increase in the inorganic nitrate group compared to the placebo group (5.17 (95% confidence interval 2.94–7.39), P < .001; difference as estimated by linear regression adjusting for baseline creatinine and diabetes status)