TABLE 1.
Patient demographics# at index and clinical characteristics during the baseline period¶
| Patients | 377 |
| Age at index, years | |
| Mean±sd | 57.4±14.2 |
| Median (IQR) | 58 (48–68) |
| ≤17 | ƒ |
| 18–25 | 6 (1.6) |
| 26–64 | 249 (66.1) |
| ≥65 | 122 (32.4) |
| Females at index | 193 (51.2) |
| CCI score during baseline | |
| 0 | 58 (15.4) |
| 1 | 226 (60.0) |
| 2 | 56 (14.9) |
| ≥3 | 37 (9.8) |
| Blood eosinophil count during baseline+, cells·µL−1 | |
| Median (IQR) | 1170 (500–4800) |
| <400 | 52 (13.8) |
| ≥400–<1000 | 76 (20.2) |
| ≥1000 | 144 (38.2) |
| Missing | 105 (27.9) |
| Clinical symptoms during baseline § | |
| Cough or breathlessness | 142 (37.7) |
| ENT involvement | 71 (18.8) |
| Nonspecific chest symptoms | 37 (9.8) |
| Skin involvement | 30 (8.0) |
| Constitutional manifestations | 28 (7.4) |
| Musculoskeletal involvement | 15 (4.0) |
| Renal involvement | 16 (4.2) |
| Gastrointestinal involvement | 21 (5.6) |
| Eye involvement | 7 (1.9) |
| Chest pain | <5## |
| Comorbid conditions at any time prior to index § | |
| Asthma | 304 (80.6) |
| Nasal polyposis | 121 (32.1) |
| Chronic rhinosinusitis | 91 (24.1) |
| Allergic rhinitis | 61 (16.2) |
| Peripheral neuropathy | 43 (11.4) |
| Ischaemic stroke | 16 (4.2) |
| COPD | 15 (4.0) |
| Cardiomyopathy | 9 (2.4) |
| Hypereosinophilic syndrome | <5## |
| Heart failure | <5## |
Data are presented as n or n (%), unless otherwise stated. IQR: interquartile range; CCI: Charlson Comorbidity Index; ENT: ear, nose and throat. #: patients from population 3; ¶: baseline period defined as the year before index (inclusive); +: the maximum value was reported if multiple values were available; §: ≥1 code for characteristic of interest; ƒ: patients aged 0–17 years were not included due to the small number (fewer than five) of patients included in this age group; ##: for clinical characteristics/conditions with fewer than five patients, Clinical Practice Research Datalink required data to be suppressed to minimise the risk of patient identification.