Table 1:
Clinical characteristics, baseline laboratory data and renal biopsy data in 16 patients.
| No. | Gender | Age, years | Clinical renal typing | Extra-renal symptoms | Immuno suppressants before TAC treatment |
Duration of IgAVN before TAC, months | TAC treatment duration, months | Urinary protein, mg/kg/day | URBC, PCS/μL | Alb, g/L | SCr, μmol/L | eGFR, mL/min/1.73 m2 | IgA, g/L | C3, g/L | Glome rular sclerosis, % |
Glome rular necrosis, % |
Tubular atrophy,% | Tubulo interstitial fibrosis,% |
Crescents, % | ISKDC grade | Tubulo interstitial injury grade |
SQC scores |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | M | 9.3 | Nephrotic syndrome | Skin purpuraAbdominal pain | CTX*13 | 37 | 36 | 68.9 | 29 | 27 | 44 | 149.16 | 1.49 | 0.98 | 15 | – | – | – | 8 | IIIa | (+) | 7 |
| 2 | M | 14.2 | Nephrotic syndromeNephritis syndrome | Skin purpura | CTX*8 + MMF | 11 | 12 | 74.8 | 310 | 30.3 | 102 | 101.92 | 1.43 | 0.9 | – | – | – | – | 60 | IV | (–) | 6 |
| 3 | M | 9.2 | Nephritis syndrome | Skin purpuraAbdominal pain | CTX*9 + MMF | 24 | 36 | 40.9 | 372 | 22.6 | 35.5 | 191.74 | 1.37 | 0.93 | – | – | – | – | 20 | IIIa | (+) | 5 |
| 4 | M | 13.6 | Nephrotic syndrome | Skin purpuraAbdominal pain | CTX*6 + MMF | 5 | 36 | 322.3 | 2720 | 17.8 | 89 | 104.29 | 1.31 | 0.58 | – | 33 | – | – | 33 | IIIb | (+) | 7 |
| 5 | M | 7.5 | Nephrotic syndromeNephritis syndrome | Skin purpuraAbdominal pain | CTX*9 + MMF | 35 | 36 | 160.8 | 561 | 19.9 | 45.2 | 140.91 | 2.74 | 0.82 | – | 67 | – | – | 44 | IIIb | (-) | 7 |
| 6 | M | 9.4 | Hematuria and proteinuria | Skin purpura | CTX*9 | 77 | 12 | 69.7 | 293 | 35.7 | 63 | 92.61 | 0.89 | 0.7 | 23 | – | 1 | 1 | – | IIIa | (++) | 12 |
| 7 | M | 6.5 | Hematuria and proteinuria | Skin purpuraAbdominal pain | CTX*9 + MMF | 32 | 36 | 46.5 | 871 | 43 | 34 | 180.18 | 1.44 | 0.7 | – | – | – | – | 9% | IIIa | (–) | 9 |
| 8 | F | 9.8 | Nephrotic syndromeNephritis syndrome | Skin purpura | CTX*9 | 25 | 30 | 211.7 | 873 | 44.9 | 51 | 132.51 | 4.16 | 1.14 | – | 53 | – | – | 27% | IIIb | (–) | 9 |
| 9 | M | 14.3 | Nephrotic syndromeNephritis syndrome | Skin purpura | CTX*8 + MMF | 10 | 6 | 175.2 | 2099 | 28.8 | 62 | 164.68 | 3.57 | 0.64 | 7 | – | 10 | – | 29% | IIIb | (++) | 9 |
| 10 | M | 10.9 | Nephrotic syndrome | Skin purpura | CTX*10 + MMF | 38 | 18 | 89.3 | 4790 | 18.2 | 123 | 57.32 | 0.876 | 0.48 | / | / | / | / | / | / | / | / |
| 11 | M | 13 | Nephrotic syndrome | Skin purpuraAbdominal pain | CTX*9 + MMF | 6 | 6 | 79.8 | 732 | 36.2 | 54 | 183.34 | 2.06 | 0.67 | – | 27 | – | – | 36% | IIIb | (++) | 9 |
| 12 | M | 13.6 | Nephrotic syndrome | Skin purpuraAbdominal painArthralgia | CTX*7 + MMF | 9 | 6 | 89.7 | 154 | 34.7 | 54 | 178.76 | 1.9 | 1.06 | 24 | – | – | – | – | IIIb | (–) | 9 |
| 13 | F | 12.1 | Nephritis syndrome | Skin purpura | CTX*8 + MMF | 14 | 6 | 2.3 | 18 | 41.9 | 62 | 121.55 | 1.42 | 1.28 | – | – | 5 | 5 | 6 | IIIb | (+) | 8 |
| 14 | F | 7.1 | Nephrotic syndrome | Skin purpuraArthralgia | CTX*8 + MMF | 23 | 6 | 55.9 | 5 | 44.1 | 30 | 191.24 | 2.17 | 1.16 | – | – | – | – | 20 | IIIa | (+) | 6 |
| 15 | F | 7.2 | Nephrotic syndrome | Skin purpura | CTX*5 + MMF | 3 | 36 | 62.4 | 153 | 28.1 | 29 | 197.83 | 0.831 | 1.01 | 8 | – | 40 | 10 | 58 | IV | (++) | 12 |
| 16 | M | 8.8 | Nephrotic syndrome | Skin purpuraAbdominal painEdema | CTX*5 + MMF | 5 | 12 | 504.6 | 2342 | 17.2 | 48.7 | 122.80 | 2.09 | 0.6 | – | – | – | – | 59 | IV | (+) | 10 |
The renal biopsy material of patient number 10 showed the absence of glomeruli.
F, female; M, male; URBC, urine erythrocyte count; Alb, albumin; SCr, serum creatinine; –, not found; /, not involve.