Table 2.
Comparison of Glandular and Squamous Precancer/Cancer Risks for women ever positive for HPV16/18/45 and/or cytological AGC.
| Ever Positive for HPV 16/18/45? | Ever Has AGC Cyto. Result? | N | % of N | AC/AIS Endpoint | SCC/CIN3 Endpoint | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| AC/AIS Cases | AC/AIS % of Cases | OR for AC/AIS (95%CI) | Attributable Risk for AC/AIS (%) | SCC/CIN3 Cases | SCC/CIN3% of Cases | OR for SCC/CIN3 (95% CI) | Attributable Risk for SCC/CIN3 (%) | ||||
| Yes | Yes | 1160 | 0.30 | 185 | 32 | 1785 (872–3656) | 32 | 228 | 4.9 | 18 (7–44) | 4.6 |
| Yes | No | 26,701 | 7.0 | 371 | 65 | 129 (55–305) | 64 | 2407 | 52 | 6.7 (5–9.1) | 44 |
| No | Yes | 4794 | 1.2 | 2 | 0.30 | 3.3 (0.4–28) | 0.21 | 66 | 1.4 | 1.0 (0.5–2.0) | 0.01 |
| No | No | 351,355 | 91 | 16 | 2.7 | 1.0 | – | 1965 | 42 | 1.0 | – |
Table 2 presents AC/AIS and SCC/CIN3 case distributions among patients ever/never positive for HPV 16/18/45 and ever/never had AGC cytology during the study period, 2006–2021 in PaP cohort. For odds ratio calculations, multinomial logistic regression is constructed with the worst histologic diagnosis being the response variable (levels are normal, glandular precancer/cancer, and squamous precancer/cancer) and ever being positive for HPV 16/18/45 and ever having AGC variables being the covariate as a combined single variable. CIN2 and CIN2/3 histologic diagnoses are grouped under the normal category of the worst histologic diagnosis variable in order to be stringent about case status. Patients that had ever tested positive for HPV 16/18/45 and ever had AGC cytology were 1785 times more likely (95%CI:872–3656) to have AC/AIS diagnosis in comparison to patients that never had HPV 16/18/45 and never had AGC cytology, which represented a greater than multiplicative effect modification. These results are from the PaP cohort and so the N’s presented are weighted sample sizes for each category. Individuals HPV-negative at enrollment were also included in this analysis. The sample sizes weight back to the HPV genotyped portion of the KPNC cohort.
AGC: atypical glandular cells; AC: adenocarcinoma; AIS: adenocarcinoma in situ; SCC: squamous cell cancer; CIN3: cervical intraepithelial carcinoma grade 3.