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The process for inclusion and exclusion of participants is delineated for each study. A total of 23 338 participants were ultimately analyzed, including 754 carriers of the V142I variant. ARIC indicates Atherosclerosis Risk in Communities; HF, heart failure; MESA, Multi-Ethnic Study of Atherosclerosis; REGARDS, Reasons for Geographic and Racial Differences in Stroke; and WHI, Women’s Health Initiative.
