Table 1. Clinical Characteristics of the Pooled Study Cohorts by V142I Carrier Status at Baseline Visit.
| V142I noncarriers (n = 22 584) | V142I carriers (n = 754) | |
|---|---|---|
| Study cohort, No. (%) | ||
| Atherosclerosis Risk in Communities | 3431 (15.2) | 112 (14.9) |
| Multi-Ethnic Study of Atherosclerosis | 1535 (6.8) | 49 (6.5) |
| Reasons for Geographic and Racial Differences in Stroke | 8265 (36.6) | 262 (34.7) |
| Women’s Health Initiative | 9353 (41.4) | 331 (43.9) |
| Participant characteristics | ||
| Age, mean (SD), y | 62 (9) | 61 (9) |
| Sex, No. (%) | ||
| Female | 17 308 (76.6) | 591 (78.4) |
| Male | 5276 (23.4) | 163 (21.6) |
| Clinical characteristics | ||
| Physical examination | ||
| Systolic blood pressure, mean (SD), mm Hg [No.] | 131 (18) [22 534] | 131 (19) [752] |
| Diastolic blood pressure, mean (SD), mm Hg [No.] | 78 (10) [22 527] | 78 (11) [753] |
| Heart rate, mean (SD), beats/min [No.] | 69 (19) [22 441] | 68 (13) [746] |
| Body mass index, mean (SD) [No.]a | 30.7 (6.6) [22 435] | 30.2 (6.7) [748] |
| Comorbidities, No./total (%) | ||
| Hypertension | 13 965/22 174 (63.0) | 460/744 (61.8) |
| Obesity | 10 789/22 435 (48.1) | 326/748 (43.6) |
| Diabetes | 4909/22 349 (22.0) | 156/748 (20.9) |
| Coronary heart disease | 1570/22 544 (7.0) | 51/753 (6.8) |
| Laboratory testing | ||
| Glucose, mg/dL | ||
| Mean (SD) [No.] | 109 (45) [20 670] | 108 (45) [684] |
| >125 mg/dL, No. (%) | 3249 (15.7) | 99 (14.5) |
| Creatinine, mg/dL | ||
| Mean (SD) [No.] | 0.93 (0.59) [20 468] | 0.89 (0.37) [677] |
| >1.5 mg/dL, No. (%) | 692 (3.4) | 21 (3.1) |
| Low-density lipoprotein cholesterol, mg/dL | ||
| Mean (SD) [No.] | 131 (41) [20 216] | 131 (40) [669] |
| ≥190 mg/dL, No. (%) | 1691 (8.4) | 49 (7.3) |
SI conversion factors: To convert cholesterol to mmol/L, multiply by 0.0259; creatinine to μmol/L, multiply by 88.4; and glucose to mmol/L, multiply by 0.0555.
a
Calculated as weight in kilograms divided by height in meters squared.