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. Author manuscript; available in PMC: 2024 May 13.
Published in final edited form as: Mol Cell. 2023 Sep 7;83(17):3095–3107.e9. doi: 10.1016/j.molcel.2023.08.006

Figure 2. Perturbing the nucleus leads to nucleolar shape changes.

Figure 2.

(A) Nucleolar shape could be set by constraints from the chromatin container (left) or an intrinsic asphericity (right).

(B) Nucleoli get less circular upon siRNA knockdown of Lamin A. Scale bar, 10 μm.

(C) Nucleolar circularity decreases upon knockdown of Lamin and degradation of HP1. Significance tested with Mann-Whitney U test. Lamin KD: p = 5 3 10−8. HP1 degradation: p = 2 3 10−7. Error bars are error on the mean.