Table 2. Inhibitory Activities of 4, 5, 6, 7, and 8 against Aggregation of V30M-TTRb.
| compound | IC50 (μM) |
|---|---|
| 4 | 6.5 ± 0.4 |
| 5 | 6.1 ± 0.5 |
| 6 | 5.0 ± 0.2 |
| 7 | 5.4 ± 0.3 |
| 8 | 5.2 ± 0.5 |
| 1a | 5.5 ± 0.5 |
| 3a | 4.5 ± 0.2 |
a
The data are from our previous study.36
b
The inhibitory activity is represented by the half-maximal inhibitory concentrations (IC50) against amyloid aggregation of V30M-TTR. The TTR concentration is 10 μM (tetramer concentration). The IC50 values of 1 and 3 are also indicated for comparison. Each experiment was independently conducted three times. All results are presented as average values with their corresponding standard deviations.