Table 6. Pharmacokinetic Parameters of 4, 5, 6, 7, 8, and 1 from an In Vivo Pharmacokinetic Study.

compound	route	dose (mg/kg)	C0 or Cmax (ng/mL)	CLtot (mL/h/kg)	Vdss (mL/kg)	AUC0–8h (ng/mL·hr)	BA (%)
4	iv	0.1	1543	24.3	153	2961
	po	0.1	240			1489	50.3
5	iv	0.1	1743	20.6	113	3708
	po	0.1	390			2476	66.8
6	iv	0.1	1718	20.6	112	3726
	po	0.1	395			2524	67.7
7	iv	0.1	1337	39.7	269	1746
	po	0.1	77			350	20.1
8	iv	0.1	1645	26.4	123	3102
	po	0.1	303			1918	61.8
1	iv	0.1	519	5.96	311	2363
	po	0.1	235			1500	63.5