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. 2024 May 13;22:193. doi: 10.1186/s12916-024-03397-w

Table 1.

Examples of candidate indicatorsa linked to falls/fall injuries

Candidate indicators Median “necessity” rating after rating round 2 Accepted for the 3rd round
ADR: falls and fall-related injuries
A. History of fall and prescribed one single antidepressant with sedating, anticholinergic, or orthostatic properties (TCA, mirtazapine, or trazodone) 7 Accepted
B. History of fall and prescribed one single antidepressant with sedating, anticholinergic, or orthostatic properties (TCA, mirtazapine, or trazodone) with one further fall risk-increasing drug 8 Redundant
C. History of fall and prescribed one single antidepressant with sedating, anticholinergic, or orthostatic properties (TCA, mirtazapine, or trazodone) with two or more further fall risk-increasing drugs 9 Redundant

aMultiple variations of candidate indicators were rated in order to identify thresholds beyond which a critical review of antidepressant use was considered necessary. Candidate indicators B and C were found to be redundant after candidate indicator A was accepted (necessity rating of ≥ 7)