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. 2024 May 13;25:120. doi: 10.1186/s13059-024-03258-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Evolutionary relationships of filoviruses and filovirus-derived EVEs. Bootstrapped maximum likelihood phylogenies showing the evolutionary relationships between filoviruses and filovirus EVEs in the nucleoprotein (NP) and viral protein 35 (VP35) genes. Phylogenies were constructed using maximum likelihood as implemented in RAxML, and codon-aligned nucleotides for each gene. Numbers adjacent internal nodes indicate bootstrap support (1000 bootstrap replicates). The scale bar indicates evolutionary distance in substitutions per site. Virus taxon names are shown in regular font, EVE names are shown bold. EVE names follow standardized nomenclature (see “Materials and methods”). Brackets to the right of each tree indicate virus genera (italics) and major lineages (bold). Silhouettes indicate host groups following the key. For Ebola virus, Bundibugyo virus, and Tai Forest virus, the main reservoir hosts are unknown. The inset box adjacent these taxa show host species in which one or more of these viruses has been isolated [81, 82], following the key. *Experimentally investigated locus [83, 84]